Key result
Patients with chronic obstructive pulmonary disease had a significantly higher atherogenic index compared to healthy controls (p<0.001), with the risk increasing alongside disease severity.
Why the study?
The study investigated lipid parameters and the atherogenic index in atherosclerosis and cardiovascular disease risk development among patients with chronic obstructive pulmonary disease.
Do patients with chronic obstructive pulmonary disease have an altered lipid profile and higher atherogenic index compared to healthy controls?
Case-Control (n=144)
No
Do patients with chronic obstructive pulmonary disease have an altered lipid profile and higher atherogenic index compared to healthy controls?
p-value: p=<0.001
COPD patients exhibit significant dyslipidemia and a higher atherogenic index compared to healthy controls, indicating an increased risk for future cardiovascular events.
Objectives: The present study’s design investigated the lipid parameters level and atherogenic index in atherosclerosis and cardiovascular disease risk development in chronic obstructive pulmonary disease patients. Methods: The study consists of 108 clinically diagnosed and confirmed spirometry-stable chronic obstructive pulmonary disease (COPD) patients (Mild, Moderate, and Severe), and the controls were 36 healthy individuals of the same age and sex. Blood samples were collected and the lipid profile was done. The atherogenic index of all COPD patients was calculated using the values of lipid parameters. Results: The observation revealed that as compared to the control group, total cholesterol, triglycerides, low-density lipoproteins (LDL), and very LDLs were significantly (p<0.001) raised in all the COPD sub-groups, and high-density lipoproteins levels showed significantly (p<0.001) decreasing levels in all COPD groups as compared to controls. The COPD sub-group has a higher atherogenic risk (p<0.001) than controls. Conclusion: In COPD patients with dyslipidemia, there is an increased atherogenic risk, which predicts future cardiovascular risk.
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FATIMA et al. (2022) conducted a case-control in Chronic Obstructive Pulmonary Disease (n=144). Chronic obstructive pulmonary disease vs. Healthy controls was evaluated on Atherogenic index (p=<0.001). Patients with chronic obstructive pulmonary disease had a significantly higher atherogenic index compared to healthy controls (p<0.001), with the risk increasing alongside disease severity.
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