Key result
Metabolic syndrome-associated risk factors and hs-CRP independently predicted arterial stiffness, with baPWV increasing progressively with the number of risk factors (P for trend <0.001).
Why the study?
Do metabolic syndrome-associated risk factors and hs-CRP predict arterial stiffness in subjects with and without chronic kidney disease?
Cross-Sectional (n=9,903)
Do metabolic syndrome-associated risk factors and hs-CRP predict arterial stiffness in subjects with and without chronic kidney disease?
p-value: p=<0.001
Metabolic syndrome-associated risk factors and hs-CRP are independent determinants of arterial stiffness in both CKD and non-CKD subjects, while renal function decline contributes to arterial stiffness specifically in CKD.
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Metabolic risks and hs-CRP predict stiffness across CKD status; extends associations but leaves causal inference and intervention effects open.
Tsai et al. (2015) conducted a cross-sectional in Chronic Kidney Disease and Metabolic Syndrome (n=9,903). Metabolic syndrome-associated risk factors and hs-CRP vs. Absence or lower levels of risk factors was evaluated on brachial-ankle pulse wave velocity (baPWV) (p=<0.001). Metabolic syndrome-associated risk factors and hs-CRP independently predicted arterial stiffness, with baPWV increasing progressively with the number of risk factors (P for trend <0.001).
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