Factors released from endocardium of the ferret and pig modulate myocardial contraction.
Population
Isolated heart muscle preparations (ferret papillary muscle) and porcine cultured endocardial cells
Comparison
Selective removal of endocardium, application of… vs Endocardium-intact preparations
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Endocardial humoral factors may modulate contractility; leaves open relevance to intact hearts and human physiology.
Structured PICO
P
Population
Isolated heart muscle preparations (ferret papillary muscle) and porcine cultured endocardial cells
I
Intervention
Selective removal of endocardium, application of 8-bromo-cyclic GMP, sodium nitroprusside, atrial natriuretic peptide (ANP), substance P, and effluent from porcine cultured endocardial cells
C
Comparator
Endocardium-intact preparations
O
Outcome
Changes in contractile behavior (inotropic effect) and myocardial cyclic GMP levelssurrogate
This study demonstrates that the endocardium releases a humoral factor that modulates myocardial contraction, providing insight into endocardial-myocardial interactions.
Cite This Study
Smith et al. (1991) studied this question.