Chronic muco-cutaneous candidiasis: new approaches to treatment

SUMMARY Chronic muco-cutaneous candidiasis may be associated with several defined syndromes of immunodeficiency or may be the predominant feature in a group of diseases, some of which are genetically determined. Current therapeutic approaches are discussed in relation to each clinical group, with particular reference to immunological reconstitution, correction of iron deficiency and other nutritional deficiencies. The effects of two new antifungal agents are considered, as well as the use of parenteral amphotericin B in a low dose. The possible use of combined therapy is outlined in patients who are more severely affected.