Key result
Treatment with either Angiotensin II or Angiotensin-(1-7) increased the proliferation of stem cells from human dental apical papilla, mediated by AT2 receptor activation.
Why the study?
The effects of the renin-angiotensin system on stem cells isolated from human dental apical papilla were completely unknown.
Does treatment with Angiotensin II or Angiotensin-(1-7) increase proliferation in stem cells from human dental apical papilla?
Does treatment with Angiotensin II or Angiotensin-(1-7) increase proliferation in stem cells from human dental apical papilla?
Angiotensin II and Ang-(1-7) stimulate the proliferation of stem cells from human dental apical papilla via AT2 receptor activation, highlighting a role for the renin-angiotensin system in dental stem cell biology.
No clinical implications yet; leaves open RAS modulation to enhance dental stem cell proliferation in future studies.
The effects of the renin-angiotensin system (RAS) on stem cells isolated from human dental apical papilla (SCAPs) are completely unknown. Therefore, the aim of this study was to identify RAS components expressed in SCAPs and the effects of angiotensin (Ang) II and Ang-(1-7) on cell proliferation. SCAPs were collected from third molar teeth of adolescents and maintained in cell culture. Messenger RNA expression and protein levels of angiotensin-converting enzyme (ACE), ACE2, and Mas, Ang II type I (AT1) and type II (AT2) receptors were detected in SCAPs. Treatment with either Ang II or Ang-(1-7) increased the proliferation of SCAPs. These effects were inhibited by PD123319, an AT2 antagonist. While Ang II augmented mTOR phosphorylation, Ang-(1-7) induced ERK1/2 phosphorylation. In conclusion, SCAPs produce the main RAS components and both Ang II and Ang-(1-7) treatments induced cell proliferation mediated by AT2 activation through different intracellular mechanisms.
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Macedo et al. (2020) studied this question. Angiotensin II and Angiotensin-(1-7) was evaluated on Cell proliferation and intracellular mechanisms. Treatment with either Angiotensin II or Angiotensin-(1-7) increased the proliferation of stem cells from human dental apical papilla, mediated by AT2 receptor activation.
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