Key result
This review critically appraises the signaling mechanisms of AT1 and AT2 receptors, their opposing physiological effects, and their interaction with ceramide in cardiovascular health and disease.
Understanding the distinct and often opposing signaling mechanisms of AT1 and AT2 receptors, along with their interaction with ceramide, provides important mechanistic insights into the cardiovascular effects of renin-angiotensin system inhibitors.
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Mechanistic insights into AT1/AT2-ceramide signaling extend basic knowledge; leaves open targeted RAS modulation for prospective cardiovascular trials.
Berry et al. (2001) conducted a review in Cardiovascular disease and hypertension. This review critically appraises the signaling mechanisms of AT1 and AT2 receptors, their opposing physiological effects, and their interaction with ceramide in cardiovascular health and disease.
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