Key result
Perindopril significantly augmented capillary density (up to 543.9 vs 364.5/mm2; P<0.005) and limb perfusion in the ischemic hindlimb of spontaneously hypertensive rats.
Why the study?
Does perindopril improve angiogenesis and perfusion in the ischemic limb of spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) with ischemia induced in the hindlimb by excision of the femoral artery
Comparison
Perindopril for 3 weeks vs Vehicle
Design
Preclinical, randomly assigned
Follow-up
4 weeks
Authors
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Hypothesis-generating for ACE inhibition in hypertensive PAD; human trials required before clinical consideration.
RCT
Randomized
Does perindopril improve angiogenesis and perfusion in the ischemic limb of spontaneously hypertensive rats?
Absolute Event Rate: 543.9% vs 364.5%
p-value: p=<0.005
ACE inhibition with perindopril reverses impaired pathological angiogenesis and improves perfusion in the ischemic limbs of spontaneously hypertensive rats.
S Takeshita (2001) conducted an RCT in Tissue ischemia in hypertension (animal model). Perindopril vs. Vehicle was evaluated on Capillary density of the ischemic limb muscles at 4 weeks (p=<0.005). Perindopril significantly augmented capillary density (up to 543.9 vs 364.5/mm2; P<0.005) and limb perfusion in the ischemic hindlimb of spontaneously hypertensive rats.
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