The role of miR‐4284 in cancer progression and therapeutic response: Regulatory mechanisms and clinical implications

As a pivotal microRNA (miRNA), miR‐4284 exhibits noteworthy aberrant expression levels across various cancers and diseases, exerting a crucial role in modulating cancer progression and prognosis. This article endeavors to comprehensively elucidate the regulatory mechanisms of miR‐4284 in cancer, delving deeply into its impact on tumor cell proliferation, invasion, and metastasis by intervening in key signaling pathways such as p65, mitogen‐activated protein kinase (MAPK), and transforming growth factor‐β (TGF‐β). Moreover, this article examines the potential associations of miR‐4284 with diverse current therapeutic strategies, such as cancer prediction models, synergistic effects of chemotherapeutic agents, mechanisms of ultrasound‐targeted microbubble destruction technology, and enhancement of radiotherapy. However, despite the significant strides made in miR‐4284 research, certain limitations persist. Looking ahead, we anticipate that larger‐scale and more in‐depth studies will further unveil the functional mechanisms of miR‐4284 and elucidate its role in therapeutic drug efficacy, thus furnishing robust theoretical underpinnings for the clinical application of miR‐4284.