Key result
The ACE I/D polymorphism was not associated with submaximal or maximal cardiovascular hemodynamics, independently or interacting with habitual physical activity levels, in young women.
Why the study?
Does the ACE I/D polymorphism associate with cardiovascular hemodynamics during exercise in young women?
Cross-Sectional (n=77)
Does the ACE I/D polymorphism associate with cardiovascular hemodynamics during exercise in young women?
The ACE I/D polymorphism is not associated with cardiovascular hemodynamics during submaximal or maximal exercise in young women.
No association in young women; leaves open genetic effects on hemodynamics in other populations or study designs.
The ACE I/D polymorphism has been shown to interact with habitual physical activity levels in postmenopausal women to associate with submaximal and with maximal exercise hemodynamics. This investigation was designed to assess the potential relationships between ACE genotype and oxygen consumption (VO2), cardiac output (Q), stroke volume (SV), heart rate (HR), blood pressure (BP), total peripheral resistance (TPR), and arteriovenous oxygen difference ([a-v]O2 diff) during submaximal and maximal exercise in young sedentary and endurance-trained women. Seventy-seven 18-35-yr-old women underwent a maximal exercise test and a number of cardiac output tests on a treadmill using the acetylene rebreathing technique. ACE genotype was not significantly associated with VO2max (II 41.4+/-1.2, ID 39.8+/-0.9, DD 39.8+/-1.1 ml/kg/min, p=ns) or maximal HR (II 191+/-2, ID 191+/-1, DD 193+/-2 bpm, p=ns). In addition, systolic and diastolic BP, (a-v)O2 diff, TPR, SV, and Q during maximal exercise were not significantly associated with ACE genotype. During submaximal exercise, SBP, Q, SV, HR, TPR, and (a-v)O2 diff were not significantly associated with ACE genotype. However, the association between diastolic BP during submaximal exercise and ACE genotype approached significance (p=0.08). In addition, there were no statistically significant interactions between ACE genotype and habitual physical activity (PA) levels for any of the submaximal or the maximal exercise hemodynamic variables. We conclude that the ACE I/D polymorphism was not associated, independently or interacting with habitual PA levels, submaximal, or maximal cardiovascular hemodynamics in young women.
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Roltsch et al. (2005) reported a cross-sectional. ACE I/D polymorphism vs. Other ACE genotypes was evaluated on Cardiovascular hemodynamics during submaximal and maximal exercise (VO2, Q, SV, HR, BP, TPR, [a-v]O2 diff) (p=ns). The ACE I/D polymorphism was not associated with submaximal or maximal cardiovascular hemodynamics, independently or interacting with habitual physical activity levels, in young women.
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