Key result
The ACE I/D polymorphism was associated with adiposity and blood pressure, with the II genotype showing lower systolic BP (109.4 vs 116.4 mmHg, p=0.035) and body fat (19.3% vs 27.3%, p=0.030).
Why the study?
There is controversy regarding the relationship between the ACE I/D polymorphism and health outcomes.
Does ACE I/D polymorphism influence cardiometabolic risk, maximal fat oxidation, cardiorespiratory fitness, diet, and physical activity in healthy young adults?
Comparison
ACE I/D polymorphisms (DD vs ID vs II genotypes)
Design
Cross-sectional study
Authors
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May inform early cardiometabolic risk stratification in young adults; leaves open causality and clinical utility.
Cross-Sectional (n=74)
Does ACE I/D polymorphism influence cardiometabolic risk, maximal fat oxidation, cardiorespiratory fitness, diet, and physical activity in healthy young adults?
The ACE II genotype is associated with lower systolic blood pressure and body fat compared to DD and ID genotypes in healthy young adults, suggesting a protective cardiometabolic effect.
Montes‐de‐Oca‐García et al. (2021) conducted a cross-sectional in healthy adults (n=74). ACE I/D polymorphism vs. Different genotypes (DD, ID, II) was evaluated on cardiometabolic risk, maximal fat oxidation, cardiorespiratory fitness, physical activity and diet. The ACE I/D polymorphism was associated with adiposity and blood pressure, with the II genotype showing lower systolic BP (109.4 vs 116.4 mmHg, p=0.035) and body fat (19.3% vs 27.3%, p=0.030).
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