Key result
The ACE ID polymorphism does not play a major role in cardiorespiratory endurance, although Caucasian offspring DD homozygotes had a 14-38% greater increase in VO2 max than II homozygotes.
Why the study?
Does the ACE ID polymorphism affect fitness phenotypes in response to a 20-week endurance training program in sedentary subjects?
Population
724 sedentary Caucasian (n=476) and black (n=248) subjects from the HERITAGE Family Study
Comparison
20-week standardized endurance training program vs Comparison between ACE insertion/deletion…
Design
Cohort
Follow-up
20 weeks
Authors
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ACE ID testing should not guide endurance training expectations; leaves open modest ancestry-specific VO2 max effects.
Observational (n=724)
Does the ACE ID polymorphism affect fitness phenotypes in response to a 20-week endurance training program in sedentary subjects?
p-value: p=0.042 to 0.0001
The study does not support the hypothesis that the ACE ID polymorphism plays a major role in cardiorespiratory endurance response to training.
Rankinen et al. (2000) conducted an observational in Sedentary (n=724). ACE insertion (I)/deletion (D) polymorphism vs. Other ACE genotypes (e.g., II homozygotes) was evaluated on Fitness phenotypes including oxygen uptake, work rate, and heart rate before and after endurance training (p=0.042 to 0.0001). The ACE ID polymorphism does not play a major role in cardiorespiratory endurance, although Caucasian offspring DD homozygotes had a 14-38% greater increase in VO2 max than II homozygotes.
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