Key result
The ACE II genotype was associated with greater improvements in medium-duration aerobic endurance, whereas the DD genotype was more advantageous for shorter-duration, higher-intensity activities.
Why the study?
Does ACE I/D gene polymorphism influence aerobic endurance development in response to training in non-elite female athletes?
Cohort (n=55)
Does ACE I/D gene polymorphism influence aerobic endurance development in response to training in non-elite female athletes?
p-value: p=<0.01
The ACE II genotype is associated with better improvements in medium-duration aerobic endurance, whereas the ACE DD genotype is more advantageous for shorter-duration, higher-intensity endurance activities.
Should not yet guide training by ACE genotype in female athletes; hypothesis-generating and requires randomized confirmation.
Aim. The aim of this study was to investigate the association between ACE gene polymorphism and short- and medium-duration aerobic endurance performance improvements in response to the same training regimen in a non-elite female cohort. Methods. Fifty-five female non-elite Caucasian Turkish athletes trained to enhance running speeds corresponding to 70% and 90% of heart rate reserve (V-HRR70 and V-HRR90 respectively) 30 min running speed performance (V-30min) 3 times per week, for 6 weeks. ACE gene polymorphisms studied by PCR analysis. Results. The distribution of genotypes in the whole cohort was 21.8%, 41.8%, 36.4% for II (n=12), ID (n=23) and DD (n=20), respectively. Subjects with ACE II genotype had significantly higher improvements in V-30min and V-HRR70 than the ACE DD group (P ID>DD (P ID>II (P<0.01) observed in V-HRR90. Conclusion. ACE II genotype may related with better improvements in medium duration aerobic endurance performance whilst ACE DD genotype seems to be more advantageous in performance enhancement in shorter duration and higher intensity endurance activities.
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Çam et al. (2006) conducted a cohort in Healthy athletes (n=55). ACE gene polymorphism (II, ID, DD genotypes) vs. Comparison between genotypes was evaluated on Improvements in running speeds corresponding to 70% and 90% of heart rate reserve and 30 min running speed performance (p=<0.01). The ACE II genotype was associated with greater improvements in medium-duration aerobic endurance, whereas the DD genotype was more advantageous for shorter-duration, higher-intensity activities.
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