ACE-I/D Allele Modulates Improvements of Cardiorespiratory Function and Muscle Performance with Interval-Type Exercise
Key result
Eight weeks of interval training improved aerobic peak power output by 4% in ACE I-allele carriers but not in non-carriers, demonstrating genotype-specific adaptations to exercise.
Why the study?
It was unknown whether the ACE-I/D genotype is associated with variability in the effects of interval-type training on peripheral muscle performance, cardiovasculature, and post-exercise recovery.
Does the ACE-I/D genotype modulate improvements in cardiorespiratory function and muscle performance following 8 weeks of interval-type training in healthy subjects?
Population
9 healthy subjects
Comparison
Interval training effects compared between carriers and non-carriers of the ACE I-allele
Design
Single-arm pre-post training study
Authors
Discussion
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Implication
ACE I-allele may modulate interval training gains; hypothesis-generating and should not yet change exercise prescriptions.
Study Design
Type
Cohort (n=9)
Structured PICO
Does the ACE-I/D genotype modulate improvements in cardiorespiratory function and muscle performance following 8 weeks of interval-type training in healthy subjects?
P
Population
9 healthy subjects, mean age 39.0 ± 14.7 years, weight 64.6 ± 16.1 kg, height 173.6 ± 9.9 cm.
I
Intervention
Eight weeks of interval training on a soft robotic device based on repeated sets of a pedaling exercise at a matched intensity relative to peak aerobic power output.
C
Comparator
Pre-training baseline and comparison between carriers and non-carriers of the ACE I-allele.
O
Outcome
Peak anaerobic and aerobic power output, mechanical work, metabolic stress (oxygen saturation and hemoglobin concentrations of Musculus vastus lateralis and Musculus gastrocnemius), blood lactate, heart rate, and systolic and diastolic blood pressure.surrogate
The ACE-I/D genotype modulates physiological adaptations to interval training, with I-allele carriers showing distinct improvements in aerobic peak power and muscle perfusion compared to non-carriers.
Cite This Study
Gasser et al. (2023) conducted a cohort in Healthy subjects (n=9). Interval training on a soft robotic device vs. ACE I-allele non-carriers was evaluated on Peak anaerobic and aerobic power output, mechanical work, and metabolic stress. Eight weeks of interval training improved aerobic peak power output by 4% in ACE I-allele carriers but not in non-carriers, demonstrating genotype-specific adaptations to exercise.