Key result
High-intensity exercise increased serum Angiotensin II levels two-fold, and subjects with the ACE-II genotype demonstrated 1.8 times higher post-exercise capillary perfusion compared to those with the ACE-ID/DD genotype.
Why the study?
Does exercise intensity and duration affect serum Angiotensin II levels and capillary perfusion in healthy subjects, and is this modulated by ACE I/D genotype?
Population
10 healthy young subjects (mean age 29.6 years)
Comparison
Three exercise tests on separate occasions: a… vs Baseline measurements and comparison between ACE…
Design
Cohort
Follow-up
Immediate post-exercise (up to 12 minutes)
Authors
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May support genotype-informed exercise responses; hypothesis-generating in healthy cohorts and requires prospective validation before clinical application.
Observational (n=10)
No
Does exercise intensity and duration affect serum Angiotensin II levels and capillary perfusion in healthy subjects, and is this modulated by ACE I/D genotype?
p-value: p=0.041
The rise in serum Angiotensin II after exercise is intensity-dependent, and variability in serum AngII and capillary perfusion is related to the ACE I/D polymorphism.
Ginkel et al. (2015) conducted an observational in Healthy (n=10). Exercise at different intensities vs. Baseline and between ACE I/D genotypes was evaluated on Change in serum Angiotensin II levels relative to baseline after maximal exercise test (p=0.041). High-intensity exercise increased serum Angiotensin II levels two-fold, and subjects with the ACE-II genotype demonstrated 1.8 times higher post-exercise capillary perfusion compared to those with the ACE-ID/DD genotype.
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