Why the study?
Does ACE I/D polymorphism predict overweight and abdominal adiposity in adult men?
Population
959 adult men, 25 to 75 years of age, from the Olivetti factories in Marcianise and Pozzuoli, suburbs of…
Comparison
ACE I/D polymorphism, angiotensinogen M235T… vs ID or II genotype (for ACE I/D polymorphism)
Design
Cohort
Follow-up
20 years (for a subset of 314 men)
Authors
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Does not support ACE genotyping for adiposity risk; hypothesis-generating for renin-angiotensin variants in metabolic outcomes.
Does ACE I/D polymorphism predict overweight and abdominal adiposity in adult men?
The ACE DD genotype is a significant predictor of overweight, abdominal adiposity, and age-related increases in body weight and blood pressure in men.
Strazzullo et al. (2003) studied this question.
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