Key result
The ACE I/D DD genotype was significantly associated with early development of hypertension compared to the II genotype (OR 2.50; 95% CI 1.19-5.25).
Why the study?
Are polymorphisms of the renin-angiotensin system genes associated with the early development of hypertension in young adults?
Case-Control (n=244)
Are polymorphisms of the renin-angiotensin system genes associated with the early development of hypertension in young adults?
Odds Ratio: 2.5 (95% CI 1.19–5.25)
ACE gene polymorphisms (I/D and T-3892C) and BMI are independent predictors of premature hypertension in young adults.
Authors
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May inform genetic risk models for early hypertension; hypothesis-generating for RAS polymorphisms and requires prospective validation.
Barbalić et al. (2006) conducted a case-control in Hypertension (n=244). ACE I/D DD genotype vs. ACE I/D II genotype was evaluated on Hypertension (OR 2.50, 95% CI 1.19-5.25). The ACE I/D DD genotype was significantly associated with early development of hypertension compared to the II genotype (OR 2.50; 95% CI 1.19-5.25).
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