Key result
The ACE II genotype was significantly more frequent in extremely obese patients with T2DM compared with controls (P<0.05) and non-diabetic extremely obese patients (P<0.01).
Population
Polish individuals with extreme obesity (with or without type 2 diabetes mellitus) and controls
Design
Case-control
Authors
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Suggests ACE II as potential marker in obese T2DM; hypothesis-generating and should not yet change practice or guidelines.
Case-Control
p-value: p=<0.05
ACE II homozygosity and its interaction with the AGTR1 gene may predispose individuals to extreme obesity and associated type 2 diabetes mellitus.
Pacholczyk et al. (2013) conducted a case-control in Extreme obesity and obesity-associated type 2 diabetes mellitus. ACE I/D and AGTR1 A1166C gene polymorphisms vs. Controls and non-diabetic extremely obese patients was evaluated on Extreme obesity and obesity-associated type 2 diabetes mellitus (p=<0.05). The ACE II genotype was significantly more frequent in extremely obese patients with T2DM compared with controls (P<0.05) and non-diabetic extremely obese patients (P<0.01).
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