Key result
Endurance training is linked to ~41% lower muscle deoxyhemoglobin during occlusion versus untrained status.
Why the study?
Does endurance training improve oxidative metabolism modulation during ischemia/reperfusion in healthy young men?
Cross-Sectional (n=33)
No
Does endurance training improve oxidative metabolism modulation during ischemia/reperfusion in healthy young men?
Absolute Event Rate: 12320% vs 21010%
p-value: p=0.001
Endurance training enhances the efficiency of skeletal muscle to shift between oxidative and anaerobic metabolism during ischemia and reperfusion.
Endurance training was associated with more efficient metabolic shifting during ischemia; this Level 4 cross-sectional finding leaves open causality and clinical relevance.
Endurance training is associated with skeletal muscle adaptations that regulate the oxidative metabolism during ischemia/reperfusion. The aim of this study was to noninvasively assess in vivo differences in the oxidative metabolism activity during ischemia/reperfusion between trained and untrained individuals, using near infrared spectroscopy (NIRS) combined with a vascular occlusion test (VOT) technique (NIRS-VOT). Sixteen untrained (26.3 ± 5.1 year) and seventeen trained (29.4 ± 4.9 year) healthy young adult men were submitted to a VOT (2 min baseline, 5 min occlusion, and 8 min reperfusion). Oxygen utilization was estimated from the area under the curve of the NIRS-derived deoxyhemoglobin [HHb] signal during occlusion (AUCocc). Muscle reperfusion was derived from the area above the curve (AACrep) of the [HHb] signal after cuff release. The AUCocc of the untrained participants (21010 ± 9553 % · s) was significantly larger than the AUCocc of their trained counterparts (12320 ± 3283 % · s); P = 0.001). The AACrep of the untrained participants (5928 ± 3769 % · s) was significantly larger than the AACrep of the trained participants (3745 ± 1900 % · s; P = 0.042). There was a significant correlation between AUCocc and AACrep (r = 0.840; P = 0.001). NIRS assessment of oxidative metabolism showed that trained individuals are more efficient in shifting between oxidative and anaerobic metabolism in response to ischemia and reperfusion.
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Soares et al. (2017) conducted a cross-sectional in Healthy young adult men (n=33). Endurance training vs. Untrained was evaluated on Area under the curve of deoxyhemoglobin during occlusion (AUCocc) (p=0.001). Endurance-trained individuals demonstrated a significantly smaller area under the curve of deoxyhemoglobin during occlusion compared to untrained individuals (12320 vs 21010 %·s, P=0.001), indicating more efficient metabolic shifting.
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