Key result
The IgG2a subclass delayed the onset and progression of LDV-induced polioencephalomyelitis more effectively than IgG1, IgG2b, and IgG3 subclasses.
The IgG2a subclass provides superior antibody-mediated protection against LDV-induced polioencephalomyelitis compared to other IgG subclasses.
May inform IgG subclass selection in viral CNS models; leaves open human translation.
Immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did the other subclasses. This suggests that the IgG2a predominance observed in many IgG antibody responses elicited by live viruses could, at least under some circumstances, correspond to the selection of the best protection for the infected host.
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Markine-Goriaynoff et al. (2002) studied Lactate Dehydrogenase-Elevating Virus-Induced Polioencephalomyelitis. IgG2a switch variant vs. IgG1, IgG2b, and IgG3 subclasses was evaluated on Onset and progression of LDV-induced polioencephalomyelitis. The IgG2a subclass delayed the onset and progression of LDV-induced polioencephalomyelitis more effectively than IgG1, IgG2b, and IgG3 subclasses.
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