Key result
The combination of renal sinus and perinephric fat infiltration was an independent unfavorable prognostic factor for cancer-specific survival in T3a renal cell carcinoma (HR 2.75, P=0.007).
Why the study?
Does the specific type of perirenal fat infiltration (renal sinus vs perinephric vs both) affect cancer-specific survival in patients with pT3a renal cell carcinoma?
Population
106 patients with advanced renal cell carcinoma who had a radical nephrectomy, followed prospectively at one…
Comparison
Renal sinus fat infiltration or combined RS and… vs Perinephric (PN) fat infiltration alone
Design
Cohort
Follow-up
median 2.9 years
Authors
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May refine pT3a RCC risk stratification; leaves open whether TNM staging should differentiate infiltration patterns.
Cohort (n=106)
No
Does the specific type of perirenal fat infiltration (renal sinus vs perinephric vs both) affect cancer-specific survival in patients with pT3a renal cell carcinoma?
Hazard Ratio: 2.75
p-value: p=0.007
The combination of renal sinus and perinephric fat infiltration is an independent unfavourable prognostic marker in pT3a renal cell carcinoma, suggesting the TNM classification should differentiate these types of infiltration.
Bedke et al. (2008) conducted a cohort in Advanced renal cell carcinoma (T3a) (n=106). Renal sinus and perinephric fat infiltration vs. Perinephric fat invasion alone was evaluated on Cancer-specific survival (HR 2.75, p=0.007). The combination of renal sinus and perinephric fat infiltration was an independent unfavorable prognostic factor for cancer-specific survival in T3a renal cell carcinoma (HR 2.75, P=0.007).
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