Key result
Multiple patterns of extrarenal extension significantly increased the risk of cancer-specific mortality compared to isolated involvement (HR 1.64; 95% CI 1.27-2.12; P<0.001).
Why the study?
Does the presence of multiple patterns of extrarenal extension increase the risk of disease progression and mortality in patients with T3a clear-cell renal cell carcinoma compared to isolated involvement?
Population
563 patients who underwent radical nephrectomy for pathologically confirmed T3aN0/NxM0 clear-cell renal cell…
Comparison
Multiple patterns of extrarenal extension vs Isolated involvement of perinephric fat, renal…
Design
Cohort
Authors
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Associated with higher cancer-specific mortality in T3a ccRCC; leaves open whether refined staging improves stratification.
Cohort (n=563)
Does the presence of multiple patterns of extrarenal extension increase the risk of disease progression and mortality in patients with T3a clear-cell renal cell carcinoma compared to isolated involvement?
Hazard Ratio: 1.64 (95% CI 1.27–2.12)
p-value: p=<0.001
Multiple patterns of extrarenal extension in T3a clear-cell renal cell carcinoma are associated with worse prognosis compared to isolated involvement, suggesting a need for refined risk stratification.
Shah et al. (2018) conducted a cohort in pathological stage T3a clear-cell renal cell carcinoma (ccRCC) (n=563). Multiple patterns of extrarenal extension vs. Isolated involvement of perinephric fat, renal sinus fat, or renal vein was evaluated on cancer-specific mortality (HR 1.64, 95% CI 1.27-2.12, p=<0.001). Multiple patterns of extrarenal extension significantly increased the risk of cancer-specific mortality compared to isolated involvement (HR 1.64; 95% CI 1.27-2.12; P<0.001).
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