Key result
Diuretic therapy combined with an ACE inhibitor decreased the odds of uncontrolled hypertension by 62% (p=0.005), while lack of prescription drug insurance increased the odds by over twofold.
Why the study?
What demographic, economic, and treatment-related factors are associated with uncontrolled hypertension in an affluent, elderly population?
Cross-Sectional (n=1,087)
What demographic, economic, and treatment-related factors are associated with uncontrolled hypertension in an affluent, elderly population?
Effect estimate: 62% decrease in OR
p-value: p=0.005
Uncontrolled hypertension remains highly prevalent even among affluent elderly patients, with blood pressure control significantly influenced by medication choice, comorbidities, and prescription drug insurance.
Supports exploring diuretic-ACE inhibitor regimens and insurance coverage in elderly hypertension; leaves open prospective validation before practice change.
OBJECTIVE: To explore demographic, economic, and treatment-related associations with uncontrolled hypertension in a relatively affluent, community-dwelling population. METHODS: Two home surveys of 655 and 432 subjects with a diagnosis of hypertension were completed in 1995 and 1999, respectively. Trained surveyors recorded medication history plus demographic and socioeconomic variables, as well as several measurements of blood pressure in the home. Uncontrolled hypertension was defined according to guidelines set forth by the Sixth Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Odds ratios for observing an elevated blood pressure given the patients' medication history, income, insurance coverage, demographic variables, and concomitant disease were estimated using multivariable logistic regression. RESULTS: On both occasions, >60% of the study population had an average blood pressure that was above recommended levels. Diuretic therapy alone (1995 survey) or in combination with an angiotensin-converting enzyme inhibitor (1999 survey) decreased the odds ratio for uncontrolled hypertension by 39% (p = 0.027) and 62% (p = 0.005), respectively. Lack of prescription drug insurance and a history of arthritis had negative effects, increasing the odds ratio for uncontrolled hypertension by more than twofold (p < 0.05). CONCLUSIONS: Uncontrolled hypertension occurs commonly among elderly patients notwithstanding a relatively high standard of living. The choice of medication, presence of concomitant disease, and availability of insurance may be important factors influencing blood pressure control.
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Inciardi et al. (2003) conducted a cross-sectional in Hypertension (n=1,087). Diuretic therapy in combination with an angiotensin-converting enzyme inhibitor vs. Other or no antihypertensive therapy was evaluated on Uncontrolled hypertension (62% decrease in OR, p=0.005). Diuretic therapy combined with an ACE inhibitor decreased the odds of uncontrolled hypertension by 62% (p=0.005), while lack of prescription drug insurance increased the odds by over twofold.
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