Higher mortality after myocardial infarction in patients with severe mental illness: a nationwide cohort study
Key result
Severe mental illness was associated with a markedly higher 1-year mortality after a first myocardial infarction compared to patients without severe mental illness (OR 2.11; 95% CI 1.74-2.56).
Why the study?
Does severe mental illness increase 30-day and 1-year mortality in patients with a first myocardial infarction?
Population
209,592 patients with a first diagnosis of myocardial infarction in the Swedish nationwide myocardial…
Comparison
Severe mental illness, specifically bipolar… vs Patients without severe mental illness (SMI)
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Implication
May prompt closer post-MI monitoring in severe mental illness; leaves open whether targeted interventions narrow this gap.
Study Design
Type
Cohort (n=209,592)
Multicenter
Yes
Structured PICO
Does severe mental illness increase 30-day and 1-year mortality in patients with a first myocardial infarction?
P
Population
209,592 patients with a first diagnosis of myocardial infarction in Sweden, followed for up to 1 year to assess the impact of severe mental illness on mortality.
E
Exposure
Severe mental illness (SMI), specifically bipolar disorder or schizophrenia, diagnosed prior to infarction
C
Comparator
Patients without severe mental illness (SMI)
O
Outcome
30-day and 1-year mortalityhard clinical
Main Result
Odds Ratio: 2.11 (95% CI 1.74–2.56)
Severe mental illness (bipolar disorder or schizophrenia) is associated with a roughly twofold increase in 30-day and 1-year mortality following a first myocardial infarction.
Cite This Study
Bodén et al. (2014) conducted a cohort in Myocardial infarction (n=209,592). Severe mental illness (bipolar disorder or schizophrenia) vs. No severe mental illness was evaluated on 1-year mortality (OR 2.11, 95% CI 1.74-2.56). Severe mental illness was associated with a markedly higher 1-year mortality after a first myocardial infarction compared to patients without severe mental illness (OR 2.11; 95% CI 1.74-2.56).