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September 30, 2021Circulation Heart FailureOpen Access

Clinical Heart Failure Among Patients With and Without Severe Mental Illness and the Association With Long-Term Outcomes

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Why the study?

Patients with severe mental illness have earlier onset of cardiovascular risk factors predisposing to worse future heart failure, prompting investigation into associations between severe mental illness and long-term heart failure outcomes.

Does severe mental illness worsen long-term outcomes in patients with heart failure?

Population

20 906 patients with HF in the Duke University Health System

Comparison

Patients with SMI vs without SMI

Design

Retrospective cohort study

Authors

CPChristoffer PolcwiartekDLDaniel LoewensteinDFDaniel J. Friedman

Discussion

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Member takes

Overview

Supports targeted monitoring in men with SMI and HF; leaves open causal mechanisms and intervention effects.

Structured PICO

Does severe mental illness worsen long-term outcomes in patients with heart failure?

P
Population
20,906 patients with heart failure (SMI, n=898; non-SMI, n=20,008) from the Duke University Health System from 2002 to 2017.
I
Intervention
Presence of severe mental illness (SMI) including schizophrenia, bipolar disorder, and severe depression
C
Comparator
Absence of severe mental illness (non-SMI)
O
Outcome
All-cause mortalityhard clinical

Severe mental illness is associated with increased all-cause mortality in men with heart failure and worse postprocedural outcomes overall, highlighting a need for closer follow-up.

Cite This Study

Polcwiartek et al. (2021) studied this question.

synapsesocial.com/papers/6a814d98d7cc3676436622a7https://doi.org/10.1161/circheartfailure.121.008364
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Also Consider

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  5. 5Depression and Anxiety as Risk Factors for Morbidity and Mortality After Organ Transplantation2015 · 305 citations