Why the study?
This study investigated the association between postoperative agitated delirium and the risk of dementia in patients who were cognitively intact before undergoing major inpatient surgery.
Does postoperative agitated delirium increase the risk of dementia in cognitively intact patients undergoing major surgery?
Population
10 932 cognitively intact inpatients aged 20 years or older undergoing major surgery in Taiwan
Comparison
Postoperative agitated delirium vs no postoperative agitated delirium
Design
Propensity score-matched cohort study
Key result
Postoperative agitated delirium in patients undergoing major surgery was associated with a significantly increased risk of subsequent dementia (HR 1.26; 95% CI 1.08-1.46; P=0.003).
Authors
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May warrant closer cognitive surveillance after postoperative delirium; hypothesis-generating for causality in dementia risk.
Cohort (n=10,934)
Does postoperative agitated delirium increase the risk of dementia in cognitively intact patients undergoing major surgery?
Hazard Ratio: 1.26 (95% CI 1.08–1.46)
Absolute Event Rate: 97.65% vs 70.85%
p-value: p=0.003
Postoperative agitated delirium is associated with a significantly increased risk of subsequent dementia in patients undergoing major surgery.
Sun et al. (2024) conducted a cohort in Major inpatient surgery (n=10,934). Postoperative agitated delirium vs. No postoperative agitated delirium was evaluated on Dementia (HR 1.26, 95% CI 1.08-1.46, p=0.003). Postoperative agitated delirium in patients undergoing major surgery was associated with a significantly increased risk of subsequent dementia (HR 1.26; 95% CI 1.08-1.46; P=0.003).