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February 8, 2024Russian Journal of Anesthesiology and Reanimatology

Independent predictors of agitation included preoperative hemoglobin >144 g/l, glucose >5.6 mmol/l, and intraoperative fentanyl >0.4 mg; risk factors for emergence delirium were age >60 years and high CFS score (>4).

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Why the study?

The study was conducted to improve the diagnosis of early postoperative cognitive disorders, including agitation and emergence delirium, by considering their risk factors after general anesthesia in trauma surgery.

What are the risk factors for early postoperative cognitive disorders (agitation and emergence delirium) after general anesthesia in trauma surgery?

Population

200 patients aged 45-74 years undergoing elective trauma surgery under general anesthesia

Design

Double-center prospective cohort study

Authors

NEN. V. ErmokhinaАКА. Н. КузовлевV.A. Negovsky Scientific Research Institute of General ReanimatologyPPPetr PolyakovV.A. Negovsky Scientific Research Institute of General Reanimatology

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Overview

Risk factor assessment may aid early detection of postoperative cognitive disorders after trauma surgery; leaves open validation in prospective trials.

Structured PICO

What are the risk factors for early postoperative cognitive disorders (agitation and emergence delirium) after general anesthesia in trauma surgery?

P
Population
200 patients aged 45-74 years undergoing elective trauma surgery (large joint replacement, spinal fusion surgery, transpedicular fixation of vertebrae) under general anesthesia
I
Intervention
General anesthesia for elective trauma surgery
O
Outcome
Early postoperative cognitive disorders (agitation and emergence delirium)

Emergence delirium, driven by older age and frailty, is an independent risk factor for postoperative delirium after trauma surgery, whereas agitation is driven by metabolic and pharmacological factors.

Cite This Study

Ermokhina et al. (2024) studied this question.

synapsesocial.com/papers/6a826432f2e4e6540e2a57fahttps://doi.org/10.17116/anaesthesiology202401114
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic significance of predictors of early postoperative cognitive disorders in patients after traumatic surgeries (prospective cohort study)2024
  2. 2Preoperative Factors Associated with Postoperative Change in Confusion Assessment Method Score in Hip Fracture Patients2002 · 82 citations
  3. 3Preoperative Factors Associated with Postoperative Change in Confusion Assessment Method Score in Hip Fracture Patients2002 · 100 citations
  4. 4The Impact of Monitoring Depth of Anesthesia and Nociception on Postoperative Cognitive Function in Adult Multiple Trauma Patients2021 · 21 citations
  5. 5The impact of postoperative agitated delirium on dementia in surgical patients2024 · 4 citations