What question did this study set out to answer?

This research aims to identify the presence and activation of the renin-angiotensin system in adult ventricular myocytes under stress conditions.

November 1, 1995AJP Heart and Circulatory Physiology

Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes

Q: What is the clinical evidence from this study?

Study design: Other. Population: Ischemic cardiomyopathy. Intervention: Ischemic cardiomyopathy and cellular hypertrophy. Primary outcome: Expression of genes and proteins for renin, angiotensinogen, ACE, and ANG II receptors.

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Key result

In a rat model of ischemic cardiomyopathy, adult ventricular myocytes expressed genes for the renin-angiotensin system, which were significantly upregulated during cellular hypertrophy.

Authors

XZX. ZhangAlbert Einstein College of Medicine DDDavid E. DostalHeart Failure / Cardiomyopathy KRKrzysztof ReissLittoral Research Group (United States)

Discussion

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Implication

Rat myocyte RAS expression in hypertrophy is plausible; hypothesis-generating and should not change practice.

Key Points

This research aims to identify the presence and activation of the renin-angiotensin system in adult ventricular myocytes under stress conditions.
An in vivo model of ischemic cardiomyopathy was utilized in rats.
Gene expression of renin, angiotensinogen, ACE, and ANG II receptors in myocytes was assessed.
Protein levels and binding sites for ANG II were measured in stressed myocytes.
In stressed myocytes, mRNAs for renin, ACE, and ANG II receptors significantly increased (exact figures not specified).
The percentage of myocytes expressing renin, ANG I, and ANG II was significantly higher in overloaded hearts.
An increase in ANG II binding sites per myocyte was observed in the pathological setting.

PICO

Population

Ischemic cardiomyopathy

Exposure / Comparator

Ischemic cardiomyopathy and cellular hypertrophy

Primary Outcome

Expression of genes and proteins for renin, angiotensinogen, ACE, and ANG II receptors

Cite This Study

Zhang et al. (1995) studied Ischemic cardiomyopathy. Ischemic cardiomyopathy and cellular hypertrophy was evaluated on Expression of genes and proteins for renin, angiotensinogen, ACE, and ANG II receptors. In a rat model of ischemic cardiomyopathy, adult ventricular myocytes expressed genes for the renin-angiotensin system, which were significantly upregulated during cellular hypertrophy.

synapsesocial.com/papers/6a1fe10dfd96d06e05430db8 https://doi.org/10.1152/ajpheart.1995.269.5.h1791

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Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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