Key result
Left ventricular volume overload in children with congenital heart defects was associated with significantly higher plasma BNP (55.4 ng/L) and ANP (164 ng/L) compared to other overloads (P<0.0001).
Why the study?
How do plasma BNP and ANP levels differ among children with congenital heart defects based on left versus right ventricular volume or pressure overload?
Population
84 children, including 61 with congenital heart defects with left or right ventricular volume or pressure…
Design
Cross-sectional
Authors
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Should not yet alter management in pediatric CHD; extends observations on natriuretic peptides to overload subtypes.
Cross-Sectional (n=84)
How do plasma BNP and ANP levels differ among children with congenital heart defects based on left versus right ventricular volume or pressure overload?
p-value: p=<0.0001
In children with congenital heart defects, left ventricular volume overload is associated with significantly higher plasma BNP and ANP levels compared to right ventricular volume overload or pressure overload.
Holmgren et al. (2005) conducted a cross-sectional in Congenital heart defects (n=84). Left ventricular volume overload vs. Right ventricular volume overload, pressure overload, and healthy controls was evaluated on Plasma BNP and ANP levels (p=<0.0001). Left ventricular volume overload in children with congenital heart defects was associated with significantly higher plasma BNP (55.4 ng/L) and ANP (164 ng/L) compared to other overloads (P<0.0001).
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