Key result
Late sodium current gating kinetics show divergence across species, rising in guinea pigs but falling in dogs.
Why the study?
Although late sodium current is considered a possible target for antiarrhythmic agents, several aspects of this current remained hidden.
Population
Rabbit, canine, and guinea pig ventricular myocytes
Comparison
Interspecies comparison across rabbit, canine, and guinea pig myocytes under action potential voltage clamp
Design
Preclinical comparative electrophysiological study using action potential voltage clamp
Authors
Loading...
Guinea pig INa,late models may not reflect human or canine physiology; leaves open species-specific validation before translational use.
Guinea pig models of late sodium current may not accurately reflect human or canine physiology due to fundamental differences in channel gating kinetics.
Horváth et al. (2023) studied Ventricular myocytes (preclinical model). Action potential voltage clamp (APVC) vs. Interspecies comparison was evaluated on Profile of late sodium current (INa,late) and conductance changes (GNa,late). INa,late increased monotonically in guinea pig myocytes but decreased in canine and rabbit myocytes during the action potential plateau, indicating genuine interspecies differences in gating kinetics.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: