Why the study?
Does inhibition of basal late sodium current reduce action potential duration in guinea pig ventricular myocytes?
Population
Ventricular myocytes isolated from healthy adult guinea pigs
Comparison
Late sodium current inhibitors including GS967… vs Basal physiological conditions (no inhibitor)
Design
Preclinical
Authors
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Demonstrates mechanistic proof-of-concept for late sodium current inhibition in modulating repolar.
Does inhibition of basal late sodium current reduce action potential duration in guinea pig ventricular myocytes?
Basal endogenous late sodium current, primarily generated by the NaV1.5 channel and regulated by CaMKII, is a significant contributor to the action potential duration of cardiac myocytes.
Song et al. (2017) studied this question.
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