Key result
PVC burden above 8.4% predicts LV-GLS deterioration.
Why the study?
Evaluating LV function in patients with idiopathic premature ventricular contractions and preserved LVEF, particularly at the subclinical stage, may be important for directing early treatment.
Does higher PVC burden correlate with deterioration in LV-GLS in patients with idiopathic PVC and preserved LVEF without structural heart disease?
Observational (n=122)
Does higher PVC burden correlate with deterioration in LV-GLS in patients with idiopathic PVC and preserved LVEF without structural heart disease?
Higher PVC burden is an independent predictor of subclinical left ventricular injury as measured by LV-GLS deterioration in patients with preserved LVEF.
Supports PVC burden ≥8.4% as GLS deterioration marker; leaves open whether suppression prevents progression in preserved-LVEF patients.
Background: Evaluation of left ventricular(LV) functions in patients with idiopathic premature ventricular contraction(PVC) with preserved LV Ejection Fraction(LVEF), especially in the subclinical stage, may be of great importance in terms of directing early treatment. Methods: A total of 122 patients, retrospectively recruited, were divided into three groups according to PVC burden: Group 1; 5%PVC<10%, Group 2; 10%PVC<15%, and Group 3; 15% PVC. Transthoracic echocardiography(TTE) was performed to evaluate LV parameters. Results: LV-GLS was found to be significantly lower in groups 2 and 3 with high PVC burden (18.89 ± 1.4, 17.55 ± 2.1, 16.26 ± 1.3; p<0.001 respectively). Correlation analysis revealed a positive and significant correlation between PVC burden with deterioration in LV-GLS (r:0.536; p<0.001). In addition, PVC burden was found to be an independent predictor of LV-GLS deterioration in multiple linear regression analysis(:0.525, p<0.001). The ROC curve analysis demonstrated that a PVC burden cut-off value of 8.4% was associated with a LV-GLS deterioration greater than -18, with a specificity of 75.4% and a sensitivity of 75.4% (AUC: 0.81 [0.73-0.88] 95% CI; p<0.001). Conclusions: PVC burden was an independent predictor of deterioration in LV-GLS. In the presence of subclinical LV injury associated with PVC burden, early catheter ablation strategies may be therapeutically beneficial.
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Arslan et al. (2024) conducted an observational in Idiopathic premature ventricular contraction with preserved LVEF without structural heart disease (n=122). Premature ventricular complex (PVC) burden vs. Lower PVC burden was evaluated on Left ventricular global longitudinal strain (LV-GLS) deterioration (AUC 0.81, 95% CI 0.73-0.88, p=<0.001). A premature ventricular complex burden cut-off of 8.4% predicted left ventricular global longitudinal strain deterioration greater than -18 (AUC 0.81; 95% CI 0.73-0.88; p<0.001).
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