Why the study?
To evaluate the impact of chronic premature ventricular complex burden on left ventricular function and cardiovascular outcomes, and to assess the role of pharmacological treatment.
Does high chronic PVC burden impair left ventricular function, and does pharmacological treatment improve clinical outcomes in these patients?
Does high chronic PVC burden impair left ventricular function, and does pharmacological treatment improve clinical outcomes in these patients?
A high chronic PVC burden (>20%) is associated with reduced left ventricular function and increased left atrial volume, highlighting the importance of pharmacological management to improve clinical outcomes.
High PVC burden may link to LV impairment; this Level 4 analysis leaves open causal effects and treatment benefit.
Objective: To evaluate the impact of chronic premature ventricular complex (PVC) burden on left ventricular (LV) function and cardiovascular outcomes, and to assess the role of pharmacological treatment in improving clinical outcomes. Methodology: This retrospective study was conducted at the Department of Cardiac Electrophysiology, Hayatabad Medical Complex, Peshawar, from September 2023 to July 2024. A total of 250 patients were included, divided into high PVC burden (>20%) and low PVC burden (≤20%) groups, with 125 patients in each group. Data on PVC burden, LV ejection fraction (LVEF), left atrial volume index (LAVI), and follow-up outcomes were collected. Statistical analysis included chi-square and t-tests, with significance set at p < 0.05. Results: The high PVC burden group showed significantly lower mean LVEF (42%) compared to the low PVC burden group (56%) (p < 0.001). LAVI was markedly higher in the high-burden group (34.5 mL/m² vs. 24.3 mL/m², p < 0.05). Follow-up outcomes were significantly associated with medication use; 68% of patients on medication improved, compared to 40% without medication (p < 0.05). A chi-square test revealed significant association between medication use and follow-up outcomes (p = 0.02). Conclusion: Chronic PVC burden adversely affects LV function and cardiovascular outcomes. Pharmacological treatment significantly improves clinical outcomes, underscoring the need for structured management strategies. Future research should focus on prospective studies and randomized trials to validate these findings.
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Ullah et al. (2025) studied this question.
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