Key result
Arginine vasopressin caused a 31% decrease in right ventricular contractility, whereas contractility was preserved with phenylephrine, in a canine model of acute pulmonary hypertension.
Why the study?
Does arginine vasopressin improve right ventricular function compared to phenylephrine in an experimental model of acute pulmonary hypertension?
Does arginine vasopressin improve right ventricular function compared to phenylephrine in an experimental model of acute pulmonary hypertension?
Arginine vasopressin exerts a negative inotropic effect on the right ventricle and causes pulmonary vasoconstriction in an experimental model of acute pulmonary hypertension, suggesting caution in its use when RV function is compromised.
Answers are grounded in this paper and cite their sources.
May warrant caution with vasopressin in RV compromise during acute PH; leaves open effects in human disease.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Leather et al. (2002) studied Acute pulmonary hypertension (n=7). Arginine vasopressin vs. Phenylephrine was evaluated on Right ventricular contractility measured as the slope of the preload recruitable stroke work relationship. Arginine vasopressin caused a 31% decrease in right ventricular contractility, whereas contractility was preserved with phenylephrine, in a canine model of acute pulmonary hypertension.
Synapse has enriched 10 related papers. Consider them for comparative context: