Key result
In a rabbit model of acute right ventricular failure, systemic vasopressors improved RV contractility (RVESPVR 4.8 mm Hg/mL, p=0.007) and increased cardiac output (214.8 mL/min, p=0.04).
Why the study?
Do intravenous vasopressors improve right ventricular contractility and cardiac output compared to aortic constriction in an experimental model of acute right ventricular failure?
Population
Adult New Zealand white rabbits with acute right ventricular failure induced by pulmonary artery constriction
Comparison
Intravenous norepinephrine and epinephrine… vs Aortic constriction
Design
Preclinical
Authors
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Suggests vasopressor benefit in experimental RV failure; leaves open translation to human right heart failure management.
Do intravenous vasopressors improve right ventricular contractility and cardiac output compared to aortic constriction in an experimental model of acute right ventricular failure?
In an experimental model of acute right heart failure, systemic vasopressors improved right ventricular contractility and cardiac output, suggesting potential clinical utility.
Apitz et al. (2012) studied Acute right ventricular failure. Intravenous vasopressors (norepinephrine and epinephrine) vs. Aortic constriction was evaluated on Right ventricular contractility (RVESPVR) and cardiac output. In a rabbit model of acute right ventricular failure, systemic vasopressors improved RV contractility (RVESPVR 4.8 mm Hg/mL, p=0.007) and increased cardiac output (214.8 mL/min, p=0.04).
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