Why the study?
Does milrinone alone or combined with epinephrine or dopamine improve hemodynamics and ventricular performance in a pig model of right ventricular failure?
Population
21 Danish landrace pigs with right ventricular failure induced by pulmonary artery banding
Comparison
Milrinone alone and in combination with… vs Baseline and comparison between epinephrine and…
Design
Preclinical
Follow-up
10 weeks (time from banding to evaluation)
Authors
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Milrinone with or without catecholamines fails to improve stroke volume in porcine RV failure; hypothesis-generating for clinical inotrope selection in right heart failure.
Does milrinone alone or combined with epinephrine or dopamine improve hemodynamics and ventricular performance in a pig model of right ventricular failure?
In a pig model of RV failure, milrinone with or without epinephrine or dopamine improved cardiac index and contractility but failed to improve stroke volume index due to reduced left ventricular filling.
Hyldebrandt et al. (2015) studied this question.
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