Thrombin Generation in Hemorrhage Control and Vascular Occlusion

Hippocrates and Aristotle recognized that blood clots outside the body but it was not until 1720 that John Louis Petit recognized that control of hemorrhage following amputation was associated with the blood clotting process.1 138 years later Rudolph Virchow formulated his postulates regarding clots in venous thrombosis.2 The association of blood clots with acute