Why the study?
Does p38 MAPK inhibition prevent endotoxin-induced contractile dysfunction and cytokine production in isolated rat hearts?
Population
Isolated rat hearts (Langendorff perfused model)
Comparison
Direct antegrade endotoxin infusion with prior… vs Direct antegrade endotoxin infusion without…
Design
Preclinical
Authors
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p38 MAPK inhibition merits exploration in sepsis cardiomyopathy; leaves open translation from isolated rat hearts to clinical use.
Does p38 MAPK inhibition prevent endotoxin-induced contractile dysfunction and cytokine production in isolated rat hearts?
p38 MAPK mediates endotoxin-induced myocardial contractile dysfunction and TNF-alpha production, highlighting a potential therapeutic target for sepsis-induced cardiac dysfunction.
Wang et al. (2004) studied this question.
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