Key result
Inhibition of p38 with SB239068 in MKK6bE transgenic animals attenuated cytokine induction and extracellular remodeling, improved cardiac performance, and prolonged survival.
Why the study?
Does p38 inhibition reduce inflammatory cytokine secretion and pathological remodeling in stressed myocardium?
Does p38 inhibition reduce inflammatory cytokine secretion and pathological remodeling in stressed myocardium?
Inhibition of p38 MAP kinase attenuates inflammatory cytokine production and pathological remodeling, suggesting a potential therapeutic target for heart failure.
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p38 activation induces myocyte cytokine release; leaves open whether targeting this pathway alters heart failure progression in vivo.
Li et al. (2005) studied Heart failure / stressed myocardium. p38 inhibitor (SB239068) was evaluated on Inflammatory cytokine induction, extracellular matrix remodeling, and hemodynamic function/survival. Inhibition of p38 with SB239068 in MKK6bE transgenic animals attenuated cytokine induction and extracellular remodeling, improved cardiac performance, and prolonged survival.
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