Key result
Greater midlife physical activity correlates with increased grey matter surface area but not better cognition.
Why the study?
The relationship between midlife physical activity, cognition, and brain health in later life is poorly understood, with conflicting results from previous research.
Does midlife physical activity engagement improve later-life cognition and brain health in older individuals at high-risk for Alzheimer's disease?
Population
Older individuals at high risk for Alzheimer's disease
Comparison
Varying midlife physical activity engagement
Authors
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May support brain structure in high AD risk; leaves open cognitive effects and need for prospective trials.
Observational
Does midlife physical activity engagement improve later-life cognition and brain health in older individuals at high-risk for Alzheimer's disease?
Midlife physical activity may independently contribute to later-life brain health and structural integrity in individuals at high risk for Alzheimer's disease.
Ai et al. (2023) conducted an observational in High-risk for Alzheimer's disease. Midlife physical activity was evaluated on Later-life cognition, grey matter characteristics, and resting-state functional connectivity. Greater midlife physical activity was associated with greater grey matter surface area and altered functional connectivity, though its association with cognitive function was not significant.