February 1, 1997Journal of Cardiovascular Pharmacology

Effect of Neutral Endopeptidase 24.11 Inhibition on Myocardial Ischemia/Reperfusion Injury: The Role of Kinins

View Full Paper

Ask AI

Bookmark

Why the study?

Does NEP-24.11 inhibition reduce infarct size in a rat model of myocardial ischemia/reperfusion injury?

Structured PICO

Does NEP-24.11 inhibition reduce infarct size in a rat model of myocardial ischemia/reperfusion injury?

Population

Lewis inbred rats subjected to 30 min left anterior descending coronary artery (LAD) occlusion followed by 120-min reperfusion

Intervention

NEP-24.11 inhibitor (NEPi) CGS24592, ACEi ramiprilat, or both, administered immediately before reperfusion (with or without kinin-receptor antagonist icatibant or ANP antagonist HS-142-1 administered before LAD occlusion)

Comparator

Vehicle (controls)

Outcome

Infarct size/risk areasurrogate

Inhibition of NEP-24.11 reduces myocardial ischemia/reperfusion injury in rats through a kinin-mediated mechanism.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not change clinical reperfusion practice; leaves open translation of NEPi kinin effects to human MI.

Cite This Study

Yang et al. (1997) studied this question.

synapsesocial.com/papers/6a1feaec2065d284090da3f2 https://doi.org/10.1097/00005344-199702000-00014

View Full Paper

Ask AI

Bookmark

Effect of Neutral Endopeptidase 24.11 Inhibition on Myocardial Ischemia/Reperfusion Injury: The Role of Kinins

Structured PICO

Discussion

Implication

Cite This Study

Effect of Neutral Endopeptidase 24.11 Inhibition on Myocardial Ischemia/Reperfusion Injury: The Role of Kinins

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider