Why the study?
Does acetylcholine reduce infarct size and preserve coronary endothelial function in a rat model of myocardial ischemia and reperfusion?
Population
Anaesthetized rats subjected to 20 min myocardial ischemia and 2 h of reperfusion
Comparison
Acetylcholine (ACh) in vivo treatment vs Control and sham
Design
Preclinical
Follow-up
2 hours of reperfusion
Authors
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ACh may limit infarct size via NO in rat I/R; leaves open translation to clinical reperfusion injury.
Does acetylcholine reduce infarct size and preserve coronary endothelial function in a rat model of myocardial ischemia and reperfusion?
Acetylcholine stimulates endogenous protective mechanisms during myocardial ischemia and reperfusion in rats, reducing infarct size and preserving endothelial function via nitric oxide production.
Richard et al. (1995) studied this question.
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