Why the study?
Does loss of SMAD3 signaling affect survival and cardiac remodeling after hemodynamic pressure overloading in mice?
Does loss of SMAD3 signaling affect survival and cardiac remodeling after hemodynamic pressure overloading in mice?
SMAD3 signaling plays dual roles in the heart after pressure overload, beneficially delimiting hypertrophic growth and improving survival, but deleteriously modulating myocardial fibrosis via microRNAs.
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SMAD3 loss impairs murine survival after pressure overload; leaves open its therapeutic targeting in human HF.
Divakaran et al. (2009) studied this question.
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