Population
Cat ventricular muscle strands and ventricular myocytes (with guinea-pig myocytes for comparison)
Comparison
D600 (2 microM) vs Control conditions (pre-drug)
Design
Preclinical
Follow-up
Up to 90-120 minutes
Authors
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D600 selectively blocks ICa in feline myocytes; leaves open direct ICa-K conductance linkage and human translation.
D600 effectively blocks calcium channels in cat ventricular muscle and unmasks a small transient outward current, without demonstrating a direct link between ICa and K conductance.
McDonald et al. (1984) studied this question.
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