Population
Isolated rat ventricular myocytes
Comparison
D600 (10(-9)-10(-3) M) applied externally vs Control conditions (sodium-free medium…
Design
Preclinical
Authors
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May indicate Ito-ICa channel overlap in rodents; leaves open translation to human electrophysiology.
D600 inhibits the calcium-independent transient outward current in rat ventricular myocytes, indicating potential similarities between the channels responsible for Ilo and ICa.
Lefevre et al. (1991) studied this question.
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