January 12, 1973Acta Medica Scandinavica
Cell Size and Lipolysis by Human Subcutaneous Adipose Tissue
Why the study?
Does fat cell size influence lipolysis in human subcutaneous adipose tissue?
Population
Specimens of human subcutaneous adipose tissue from subjects with marked difference in body weight, patients…
Comparison
In vitro stimulation with theophylline… vs Basal conditions and comparison across different…
Design
Preclinical
Authors
Discussion
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Implication
Fat cell size may modulate lipolysis; animal data leaves open human relevance to adipose tissue and hyperglycemia syndromes.
Structured PICO
Does fat cell size influence lipolysis in human subcutaneous adipose tissue?
P
Population
Specimens of human subcutaneous adipose tissue from subjects with marked difference in body weight, patients with recent onset of diabetes mellitus (juvenile and adult type), and obese subjects before and after intestinal shunt operation.
I
Intervention
In vitro stimulation with theophylline, N6,O2-dibutyryl 3'5' AMP, noradrenaline, and phentolamine
C
Comparator
Basal conditions (glucose 5.5 mM) and comparison across different fat cell sizes
O
Outcome
Glycerol production (lipolysis)surrogate
The size of human fat cells substantially influences their lipolytic capacity, with larger cells showing less marked lipid mobilization, which may relate to the non-ketotic hyperglycemic syndrome.
Cite This Study
Östman et al. (1973) studied this question.