Effects on Lipoprotein Subclasses of Combined Expression of Human Hepatic Lipase and Human apoB in Transgenic Rabbits
Population
Transgenic rabbits expressing human apolipoprotein B, a species naturally deficient in hepatic lipase activity
Comparison
Combined expression of human hepatic lipase and… vs Rabbits expressing human apoB alone
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications; leaves open HL's role in human LDL metabolism for prospective study.
Structured PICO
P
Population
Transgenic rabbits expressing human apolipoprotein B (apoB), a species naturally deficient in hepatic lipase activity
I
Intervention
Combined expression of human hepatic lipase (HL) and human apoB
C
Comparator
Rabbits expressing human apoB alone
O
Outcome
Changes in low-density lipoprotein (LDL) subclasses (large, small, and very small LDL protein concentrations)surrogate
Hepatic lipase directly regulates total plasma LDL concentrations and drives the production of smaller, denser LDL particles from larger precursors in a transgenic rabbit model.
Cite This Study
Rizzo et al. (2003) studied this question.