Why the study?
Does overexpression of apolipoprotein E3 alter plasma cholesterol and triglyceride metabolism in transgenic rabbits?
Population
Transgenic rabbits expressing low, medium, or high levels of human apolipoprotein E3
Comparison
Overexpression of human apolipoprotein E3 at… vs Nontransgenic rabbits
Design
Preclinical
Authors
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Provides rabbit model of apoE3-driven combined hyperlipidemia; leaves open relevance to human familial combined hyperlipidemia.
Does overexpression of apolipoprotein E3 alter plasma cholesterol and triglyceride metabolism in transgenic rabbits?
Elevated expression of apoE3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis, providing a model similar to familial combined hyperlipidemia.
Huang et al. (1999) studied this question.
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