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September 15, 1995CancerOpen Access

Thrombosis of tibial arteries in a patient receiving tamoxifen therapy

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Population

1 49-year-old female patient with breast cancer who had a total mastectomy 3 years earlier and was receiving…

Design

Case_report

Follow-up

4 months

Authors

NDNarayan DeshmukhSTSanjay P. Tripathi

Discussion

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Overview

Tamoxifen may rarely trigger arterial thrombosis treatable by urokinase; this Level 5 case leaves open causality and management guidance.

Structured PICO

P
Population
1 49-year-old female patient with breast cancer who had a total mastectomy 3 years earlier and was receiving tamoxifen therapy.
I
Intervention
Urokinase therapy and discontinuation of tamoxifen
O
Outcome
Lysis of thrombosis and restoration of normal circulation

Tamoxifen therapy may be associated with rare arterial thrombosis, which can be successfully treated with urokinase and discontinuation of the drug.

Cite This Study

Deshmukh et al. (1995) studied this question.

synapsesocial.com/papers/6a1fed2ae91b56c6af2e47adhttps://doi.org/10.1002/1097-0142(19950915)76:6<1006::aid-cncr2820760614>3.0.co;2-k
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tamoxifen and Thromboembolism1980 · 49 citations
  2. 21995 Physicians' Desk Reference1995 · 502 citations
  3. 3Antithrombin III Level, Fibrinogen Level, and Platelet Count Changes With Adjuvant Tamoxifen Therapy1992 · 67 citations
  4. 4Cancer: Principles and Practice of Oncology.1991 · 8,533 citations
  5. 5The importance of tamoxifen to a cisplatin-containing regimen in the treatment of metastatic melanoma1989 · 109 citations