Conversion of paroxysmal atrial fibrillation to sinus rhythm by intravenous pirmenol. A placebo controlled study.
Key result
Intravenous pirmenol restored sinus rhythm in 60% (12 of 20) of patients with paroxysmal atrial fibrillation compared to 15% (3 of 20) with placebo.
Why the study?
Does intravenous pirmenol restore sinus rhythm in patients with paroxysmal atrial fibrillation?
Population
n=40 patients with paroxysmal atrial fibrillation of recent onset, without congestive heart failure or a…
Comparison
Intravenous pirmenol (50-100 mg) vs Placebo
Design
RCT, Randomly allocated, Double blind
Follow-up
1 hour
Authors
Discussion
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Implication
Supports IV pirmenol for acute conversion of paroxysmal AF; confirms efficacy versus placebo in RCT.
Study Design
Type
RCT (n=40)
Blinding
Double-blind
Randomization
randomly allocated
Structured PICO
Does intravenous pirmenol restore sinus rhythm in patients with paroxysmal atrial fibrillation?
P
Population
40 patients with paroxysmal atrial fibrillation, without congestive heart failure or sinus node disorder, evaluated for restoration of sinus rhythm.
I
Intervention
Intravenous pirmenol (50-100 mg)
C
Comparator
Placebo
O
Outcome
Restoration of sinus rhythmsurrogate
Main Result
Absolute Event Rate: 60% vs 15%
Intravenous pirmenol is effective and well-tolerated for the rapid conversion of recent-onset paroxysmal atrial fibrillation to sinus rhythm.
Cite This Study
Toivonen et al. (1986) conducted an RCT in Paroxysmal atrial fibrillation (n=40). Pirmenol vs. Placebo was evaluated on Restoration of sinus rhythm. Intravenous pirmenol restored sinus rhythm in 60% (12 of 20) of patients with paroxysmal atrial fibrillation compared to 15% (3 of 20) with placebo.