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November 24, 2020Open Access

High-intensity interval training improved right cardiac mechanics during hypoxic exercise more than moderate continuous training by enhancing right atrial function and reducing pulmonary vascular resistance.

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Why the study?

The types of exercise that enhance right cardiac mechanics during hypoxic stress have not yet been identified.

Does high-intensity interval training improve right cardiac mechanics during hypoxic exercise in young, healthy, sedentary men compared to moderate-intensity continuous training or no exercise?

Population

54 young and healthy sedentary males

Comparison

HIIT vs MICT vs non-exercising control

Design

Randomized trial

Follow-up

6 weeks

Key result

High-intensity interval training improved right cardiac mechanics during hypoxic exercise more than moderate continuous training by enhancing right atrial function and reducing pulmonary vascular resistance.

Authors

YHYu-Chieh HuangAsia UniversityCHChih‐Chin HsuChang Gung UniversityTFTieh‐Cheng FuKeelung Chang Gung Memorial Hospital

Discussion

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Member takes

Overview

HIIT may be prioritized over MICT to optimize right heart function in hypoxia; extends RCT comparisons of training intensity to right atrial and pulmonary vascular measures.

Study Design

Type

RCT (n=54)

Blinding

Single-blind

Randomization

Randomized

Multicenter

No

Structured PICO

Does high-intensity interval training improve right cardiac mechanics during hypoxic exercise in young, healthy, sedentary men compared to moderate-intensity continuous training or no exercise?

P
Population
54 young, healthy, sedentary males randomized to 6 weeks of high-intensity interval training, moderate-intensity continuous training, or no exercise.
I
Intervention
High-intensity interval training (HIIT) on a stationary bicycle (3-min intervals at 40% and 80% of VO2max) for 30 min/day, 5 days/week for 6 weeks.
C
Comparator
Moderate-intensity continuous training (MICT) on a stationary bicycle (sustained 60% of VO2max) for 30 min/day, 5 days/week for 6 weeks, and a no-exercise control group (CTL) with monitored physical activity and daily diet.
O
Outcome
Right cardiac mechanics (including pulmonary vascular resistance, right ventricular ejection fraction, and right atrial reservoir/conduit functions) during semiupright bicycle exercise tests under hypoxic conditions (50 watts under 12% FIO2 for 3 min) measured using two-dimensional speckle-tracking echocardiography at 6 weeks.surrogate

In healthy sedentary men, 6 weeks of high-intensity interval training is superior to moderate-intensity continuous training in improving right ventricular ejection fraction and right atrial function while decreasing pulmonary vascular resistance during hypoxic exercise.

Limitations

  • Small sample size of young, healthy, sedentary men limits generalizability to patients with cardiovascular disease or females.
  • Potential image quality limitations of 2D-STE for thin right ventricular walls.
  • Noninvasive estimation of pulmonary vascular resistance may not reflect true absolute pressures.
  • MICT exercise volume may have been too low to induce positive cardiac hemodynamic adaptations.
  • Limited to young, healthy, sedentary men, requiring extrapolation for females or patients with abnormal cardiovascular systems
  • Potential image quality limitations of 2D-STE due to thin right ventricular walls
  • Noninvasive estimation of pulmonary vascular resistance might not reflect true absolute data
  • MICT exercise volume may have been too low to exert a positive effect on cardiac hemodynamic adaptation

Cite This Study

Huang et al. (2020) conducted an RCT in Sedentary healthy males (n=54). High-intensity interval training (HIIT) vs. Moderate-intensity continuous training (MICT) and no exercise was evaluated on Right cardiac mechanics (pulmonary vascular resistance, right ventricular ejection fraction, right atrial functions) during hypoxic exercise. High-intensity interval training improved right cardiac mechanics during hypoxic exercise more than moderate continuous training by enhancing right atrial function and reducing pulmonary vascular resistance.

synapsesocial.com/papers/6a1fee8bd4e6d3589704b119https://doi.org/10.21203/rs.3.rs-109240/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A randomized controlled trial of enhancing hypoxia-mediated right cardiac mechanics and reducing afterload after high intensity interval training in sedentary men2021 · 4 citations
  2. 2High-Intensity Interval Training Improves Left Ventricular Contractile Function2019 · 39 citations
  3. 3High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension2016 · 78 citations
  4. 4Cardiac autonomic and left ventricular mechanics following high intensity interval training: a randomized crossover controlled study2018 · 32 citations
  5. 5Cardiac remodeling after six weeks of high-intensity interval training to exhaustion in endurance-trained men2019 · 27 citations